In the burgeoning field of molecular imaging, polymeric nanoparticles are an interesting alternative owing to their higher photostability, brighter fluorescence, good biocompatibility, easy design and preparation. These nanoparticles serve the dual purpose, i.e. they act as a carrier of therapeutic agents directly delivering them to the intended site of action as well as a fluorescent marker for high-contrast in-vitro imaging. In addition to polymeric nanoparticles, lipid based nanoparticles are also used as drug carriers.
As a part of biological application of nanomaterials, we have synthesized CdSe (cadmium selenide) quantum dots (nanoparticle restricted from all three dimension), carbon dots and fluorescent polymeric nanopartciles. Some of these nanopartciles have strong two photon fluorescence and useful for multimodal imaging. Recently, along with our collaborators we are also exploring different super-resolution modalities.